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KMID : 1156220090350050362
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Journal of Environmental Health Sciences
2009 Volume.35 No. 5 p.362 ~ p.364
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Antibacterial effects of Mume Fructus Water Extract against Salmonella typhimurium in Murine Salmonellosis
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Jung Won-Chul
Cha Chun-Nam
Lee Hu-Jang
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Abstract
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The present study was undertaken to estimate the antibacterial effect of Mume Fructus water extract (MFWE) against murine salmonellosis. At MFWE concentrations ranging from 25 to 100 ㎍/ml, the antibacterial effect was not showed on Salmonella typhimurium (S. typhimurium). On the other hand, bacteria without MFWE had a tendency to proliferate up to 8 h after incubation. Oral administration of MFWE at the dose of 40 ㎎/ml showed a therapeutic effect for S. typhimurium infected BALB/c mice. The mortality of MFWE-treated mice was 80% at 12 days, while that of MFWE-untreated mice was 100% at 9 days after a lethal dose of S. typhimurium infection. The results of our study strongly indicate that MFWE has potential as an effective of salmonellosis.
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KEYWORD
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Mume Fructus water extract, antibacterial effect, salmonellosis, Salmonella typhimurium
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